Protein Details: Potassium channel subfamily K member 9

Protein ID

ICDB_Pro_1579

Protein Name

Potassium channel subfamily K member 9

Gene Name

KCNK9; TASK3

Organism

Homo sapiens (Human)

Length

374 amino acids

AlphaFoldDB

AF-Q9NPC2-F1-model_v4.pdb

Function

pH-dependent;voltage-insensitive;background potassium channel protein.

Sequence

MKRQNVRTLSLIVCTFTYLLVGAAVFDALESDHEMREEEKLKAEEIRIKGKYNISSEDYRQLELVILQSEPHRAGVQWKFAGSFYFAITVITTIGYGHAAPGTDAGKAFCMFYAVLGIPLTLVMFQSLGERMNTFVRYLLKRIKKCCGMRNTDVSMENMVTVGFFSCMGTLCIGAAAFSQCEEWSFFHAYYYCFITLTTIGFGDYVALQTKGALQKKPLYVAFSFMYILVGLTVIGAFLNLVVLRFLTMNSEDERRDAEERASLAGNRNSMVIHIPEEPRPSRPRYKADVPDLQSVCSCTCYRSQDYGGRSVAPQNSFSAKLAPHYFHSISYKIEEISPSTLKNSLFPSPISSISPGLHSFTDHQRLMKRRKSV

PDB Structures

3P1N 3P1O 3P1P 3P1Q 3P1R 3P1S 3SMK 3SML 3SMM 3SMN 3SMO 3SP5 3SPR 3UX0 4FR3 6GHP 8K1J 8K1Q 8K1V 8K1Z

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Birk-Barel Syndrome and Intellectual Disability;Birk-Barel Type

Location

Mainly found in the cerebellum. Also found in adrenal gland;kidney and lung.

DOI ID

10.1074/jbc.m000030200; 10.1016/s0169-328x(00)00183-2; 10.1152/jn.2001.86.1.130; 10.1016/s1535-6108(03)00054-0; 10.1101/gr.2596504; 10.1126/scisignal.2003431; 10.1016/j.ajhg.2008.07.010; 10.1002/ajmg.a.37740; 10.1016/j.ejmg.2019.01.009

RefSeq

NP_001269463.1; XP_011515404.1